Males can be distinguised from females because they are brightly colored and possess a dark row of pores in between their legs. They are also generally broader and bulkier than the females. The physical makeup of the males helps them become sexually active earlier than their female counterparts.

Leopard geckos usually breed throughout most of the year. A few considerations must be kept in mind if one is planning to breed geckos. First and foremost, one must have sufficient time and the financial resources to breed and raise the babies. In addition, leopard geckos require a diet that is rich in calcium before and throughout the breeding season and this can get time consuming and expensive. Apart from this, the right equipment is required to incubate and hatch the young ones and needless to say the equipment can be costly.

There are several breeding techniques that can be used to breed leopard geckos. The first technique is the so called harem technique. The harem technique involves placing a male and several females together, provided the cage has a large enough floor area. The second method of breeding, leopard geckos involves keeping the male separate from the females and then putting the females into the cage at a specified time. This method is best for selectively breeding leopard geckos especially when you want to choose specific characteristics in the leopard gecko. Similarly, by using this latter method any early or unwanted breeding can be prevented.

Within weeks after mating, the female leopard gecko will start gaining weight and the shape of the egg can be seen through the skin if her abdomen is examined. A female who is carrying eggs will not want to eat and will be restless. She may even re-arrange things in the cage. One must put a box in the cage that the gecko will lay her eggs in. The laying box can be as small as 8 *4 inches, and should not be too tall so that the gecko can easily crawl in and out. The box must also be filled with material such as moist moss.

Once the female lays the eggs, the laying box along with the eggs must be removed and must be placed in an incubator. The eggs must be removed in the position in which it was laid and it must not be tilted, agitated or turned.

Once inside the incubator, keep in mind that the gender of the gecko is determined by the temperature inside the incubator. If the temperature is in the low 80s, then the gecko will probably be a female and if the temperature is in the high 80s, then the gecko will probably be a male. So, one can determine the gender of the gecko simply by adjusting the temperature. The young ones will hatch somewhere between 1 - 2 months after which they must be moved to separate enclosures to be cared for.